Status:
COMPLETED
Dietary Intervention and Vascular Function
Lead Sponsor:
University of Reading
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
21-60 years
Phase:
NA
Brief Summary
It is well established that diet plays an important role in both the development and progression of heart disease. Different types of dietary fat have varying effects on heart disease risk factors. Th...
Eligibility Criteria
Inclusion
- Adults should have a relative risk (RR) of \> 1.5 of developing cardiovascular disease (CVD) based on presenting with at least one recognised risk factor for CVD:
- total cholesterol (TC) \> 6.0 mmol/l
- HDL cholesterol (HDLC) ≤ 1.0 mmol/l male, ≤ 1.3 mmol/l female
- Glucose ≥ 6 mmol/l
- Stage 1 hypertension or above i.e. a systolic BP ≥ 140 mmHg, diastolic BP ≥ 90 mmHg
- BMI 28-35 kg/m2
- waist \>102 cm male or \> 84 cm female
- Adults with a first degree relative with either a history of premature CVD - age of onset younger than 55 y in fathers, sons or brothers or younger than 65 y in mothers, daughters or sisters, or type 2 diabetes.
Exclusion
- having suffered a myocardial infarction/stroke in the past 12 months
- diabetic (diagnosed or fasting glucose \> 7 mmol/l) or suffer from other endocrine disorders
- suffering from renal or bowel disease or have a history of choleostatic liver or pancreatitis
- on drug treatment for hyperlipidaemia, hypertension, inflammation or hypercoagulation
- no history of alcohol abuse
- planning or on a weight reducing regime
- taking any fish oil, fatty acid or vitamin and mineral supplements
- pregnant, lactating or planning a pregnancy
- smokers
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
202 Patients enrolled
Trial Details
Trial ID
NCT01478958
Start Date
May 1 2010
End Date
October 1 2012
Last Update
July 15 2014
Active Locations (2)
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1
Department of Food and Nutritional Sciences, University of Reading
Reading, Berkshire, United Kingdom, RG6 6AP
2
University of Reading
Reading, Berkshire, United Kingdom, RG6 6AP