Status:
COMPLETED
Mitochondria and Schizophrenia: Effects of Antipsychotic Drugs
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Brief Summary
The investigators will investigate 1. the relationships between oxidative stress-, apoptosis-related markers, mitochondria DNA copy numbers and the clinical psychopathology of schizophrenia, includin...
Detailed Description
In past study, we had shown that there were significant differences in serum Lpo (lipid peroxidation) and Thiol levels between patients with schizophrenia and healthy controls. For patients taking ris...
Eligibility Criteria
Inclusion
- Schizophrenic patients will be recruited in psychiatric inpatients and outpatients departments according to DSM-IV criteria by a semi-structured interview. The assessment will be done by two senior psychiatrists. The intra- rater and inter-rater reliability will be done before this project started.
- The patients had the ability to complete the written inform consent.
Exclusion
- Alcohol abuse or dependence
- Smoking more than 1 pack per day
- Concurrent use of mood stabilizer or beta-blocker
Key Trial Info
Start Date :
August 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2013
Estimated Enrollment :
77 Patients enrolled
Trial Details
Trial ID
NCT01479413
Start Date
August 1 2009
End Date
September 1 2013
Last Update
September 11 2013
Active Locations (1)
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1
Department of Psychiatry, Chang Gung Memorial Hospital
Kaohsiung City, Taiwan