Status:
COMPLETED
Effects of Transcranial Direct Current Stimulation on the Apathy of Alzheimer's Disease
Lead Sponsor:
University of Sao Paulo
Conditions:
Apathy
Alzheimer's Disease
Eligibility:
All Genders
50+ years
Phase:
PHASE2
Brief Summary
This is a phase 2 double-blind, randomized, sham-controlled study to investigate the effects of repeated transcranial direct current stimulation for the treatment of apathy in moderate Alzheimer's Dis...
Detailed Description
Forty patients were randomized to receive either active or sham-tDCS over the left dorsolateral prefrontal cortex (DLPFC). Patients received six sessions of intervention during two weeks and were eval...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Dementia defined by DSM-IV (Diagnostic and Statistical Manual version IV)
- Possible Alzheimer's Disease defined by NINCDS-ADRDA (National Institute for Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association)
- Mini Mental State Examination scores from 10 to 20
- Apathy defined by a score equal or higher to 14 in Apathy Scale
- Exclusion criteria:
- Clinical instability
- Epilepsy
- Metallic clip in the head
- Use of alcohol and psychotropic drugs
Exclusion
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01481558
Start Date
January 1 2012
End Date
May 1 2012
Last Update
January 9 2014
Active Locations (1)
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1
University of São Paulo Medical School
São Paulo, São Paulo, Brazil, 01246903