Status:
COMPLETED
Examination of the Effectiveness of Diffusion Weighted Magnetic Resonance Imaging for Identifying Poor Prognosis in Patients With Rheumatoid Arthritis
Lead Sponsor:
Optimus Clinical Research
Collaborating Sponsors:
Arthritis Australia, Abbott Australia
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
18+ years
Brief Summary
Diffusion Weighted Imaging (DWI) MRI will assist in differentiating poor prognosis bone oedema more effectively than traditional T2 weighted MRI in patients with early Rheumatoid Arthritis (RA).
Detailed Description
Assess DWI MRI in patients with early Rheumatoid Arthritis to determine whether the MRI method will assist in differentiating poor prognosis bone oedema more effectively than traditional T2 weighted M...
Eligibility Criteria
Inclusion
- Subject has Rheumatoid Arthritis as defined by the ACR/Eular criteria
- Subject is able to understand and comply with study protocol
- Active disease as defined by DAS28\> 3.0
- Disease duration less than 12 months
- If female, subject is either not of childbearing potential, or is of childbearing potential and is practicing an approved method of birth control throughout the study
- subject is judged to be in good health as determined by the PI based upon results of medical history, laboratory profile and physical examination.
- Prednisone dose 10mg or less, dose stable for 28 days prior to baseline
Exclusion
- Inflammatory arthropathy other than Rheumatoid Arthritis
- Inactive disease as evidenced by DAS 28 CRP and / or ESR \< 2.5
- Prednisone dose greater than 10mg within 28 days prior to baseline
- Intra-articular steroid within 28 days prior to baseline visit
- IV Methyl-prednisone within 28 days prior to baseline visit
- Any contra-indication to Magnetic Resonance Imaging
- Permanent Pacemaker
- Intracerebral aneurysm clip
- Claustrophobia to the extent that patient cannot manage MRI investigations
- Implanted metallic device
- Cochlear implant
Key Trial Info
Start Date :
August 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01482507
Start Date
August 1 2011
End Date
December 1 2014
Last Update
April 6 2018
Active Locations (1)
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1
Optimus Clinical Research
Kogarah, New South Wales, Australia, 2217