Status:
COMPLETED
Early Intervention for Youth at Risk for Bipolar Disorder
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
Stanford University
University of Colorado, Boulder
Conditions:
Bipolar Disorder
Major Depressive Disorder
Eligibility:
All Genders
9-17 years
Phase:
NA
Brief Summary
Children or teens with mood swings or depression who have a parent with bipolar disorder are at high risk for developing bipolar disorder themselves. This study will test a family-based therapy aimed ...
Detailed Description
Children who are at high risk for developing bipolar disorder (BD) often are showing significant mood swings or depression well before they develop the full disorder. Often, these children have one or...
Eligibility Criteria
Inclusion
- For a child to be eligible:
- At least one biological parent or stepparent with whom the child or adolescent lives must be willing to participate in family treatment
- At least one biological parent has a verifiable diagnosis of bipolar disorder I or II
- The child must have a DSM-IV diagnosis of bipolar disorder not otherwise specified or major depressive disorder (MDD)
- If the main diagnosis is MDD, the depressive episode must have occurred within the past 2 years
- The child must have evidence of current significant affective symptoms, as determined by a score greater than 11 on the Young Mania Rating Scale within the last week or a score greater than 29 on the Child Depression Rating Scale-Revised within the last 2 weeks
- The family must speak English, although English need not be their first language
Exclusion
- Fully diagnosable bipolar disorder I or II
- Diagnosis of autism or pervasive developmental disorder
- Evidence of mental retardation, as defined by an intelligence quotient (IQ) less than 70
- Presence of comorbid neurologic diseases such as seizure disorder
- Substance or alcohol abuse or dependence disorders in the 4 months prior to study recruitment
- Evidence of a life-threatening eating disorder or other medical disorder that requires emergency medical treatment
- Currently enrolled in regular family therapy
- Evidence of current sexual or physical abuse or domestic abuse between the adult partners
Key Trial Info
Start Date :
October 6 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 15 2020
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT01483391
Start Date
October 6 2011
End Date
September 15 2020
Last Update
October 4 2021
Active Locations (3)
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1
UCLA Child and Adolescent Mood Disorders Program, UCLA School of Medicine
Los Angeles, California, United States, 90024-1759
2
Stanford University School of Medicine, Lucile Packard Children's Hospital
Stanford, California, United States, 94304
3
University of Colorado, Boulder
Boulder, Colorado, United States, 80309