Status:
COMPLETED
Absorption and Metabolism of Dietary Cocoa Procyanidins in Humans
Lead Sponsor:
University of California, Davis
Conditions:
Healthy
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether or not the intake of dietary procyanidins (oligomers of flavanols) contribute to the systemic presence of flavanols in healthy humans.
Detailed Description
Flavanols and their oligomeric derivatives, the procyanidins, are plant-derived compounds normally present in the human diet. Accumulating data demonstrate a causal role for flavanols in mediating the...
Eligibility Criteria
Inclusion
- A normal blood chemistry and liver function
- Fasting blood cholesterol and triglycerides \< 300 mg/dl and \< 3.0 mmol/l, respectively
- BMI \< 30 kg/m2 will be considered.
- Volunteers must be able to read and speak English fluently, and thus, fully understand the researchers, research protocols, and their rights as a research volunteer.
Exclusion
- A history of cardiovascular disease, stroke, uncontrolled hypertension (\> 160/90 mm), renal, hepatic, or thyroid disease, GI tract disorders, previous GI surgery, metabolic syndrome, diabetes, taking cholesterol-lowering medication, hormone replacement therapy, antioxidant supplements, on aspirin therapy or taking anticoagulants, or on a medically prescribed diet.
- A history of psychiatric illness or an allergy to peanuts.
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01483508
Start Date
February 1 2008
End Date
August 1 2008
Last Update
October 25 2012
Active Locations (1)
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1
Ragle Facility-UC Davis
Davis, California, United States, 95616