Status:
COMPLETED
Role of microRNAs in T Cell-Driven Inflammation in Asthma
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Asthma
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This will be a single center study of asthmatic subjects and healthy controls which will investigate mechanisms of asthma through detailed molecular analysis of airway tissues and fluids. The primary ...
Eligibility Criteria
Inclusion
- Group A:
- Male and female subjects between the ages of 18 and 70 years
- Group B:
- Male and female subjects between the ages of 18 and 70 years
- History of asthma
- No use of oral or inhaled corticosteroids for the treatment of asthma in the past 6 weeks
- Hyperreactivity to methacholine (PC20FEV1 Methacholine ≤ 8.0 mg/mL)
- At least one of the following symptoms, beta agonist use, or FEV1 criteria:
- Asthma symptoms on at least two days per week; OR
- Beta agonist use on at least two days per week; OR
- FEV1 \< 85% predicted
- Groups A \& B:
Exclusion
- Current smokers (smoking within the last 12 months) or former smokers who have a total pack-year smoking history greater than 10
- Pregnant women
- Subjects with a history of lung disease other than asthma
- Subjects with a history of a medical disease, which in the opinion of the investigator may put the subject at extra risk from study-related procedures or because the disease may influence the results of the study
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT01484691
Start Date
January 1 2012
End Date
July 1 2015
Last Update
June 24 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of California, San Francisco
San Francisco, California, United States, 94143