Status:
COMPLETED
Sensitivity and Specificity of Nasal Provocation Test in Allergic Rhinitis to House Dust Mites
Lead Sponsor:
University Hospital, Strasbourg, France
Conditions:
Allergic Rhinitis
Eligibility:
All Genders
18-65 years
Brief Summary
The diagnosis of allergic rhinitis to dust mites is difficult and based on three elements : suggestive symptoms of clinical sensitization to dust mites (rhinitis), the existence of an IgE sensitizatio...
Eligibility Criteria
Inclusion
- Non-smoking or smoking less than five cigarettes per day
- Subject affiliated with a social security system
- Informed consent signed and dated by the investigator and the subject
- Having been informed about the results of prior medical
Exclusion
- Moderate to severe persistent asthma (FEV \<70%)
- Treatment:
- \* H1 antihistamine (stop for less than 7 days) \* Non-steroidal analgesics (stop for less than a week)\* Central anti-hypertensive for 4 weeks- Corticosteroids: Nasal (stop for less than 7 days)Oral (if supported by more than 10 mg per day, stopping for less than a week)Intramuscular \*Imipramine and other tricyclic treatment (stop for less than a week) \*Ketotifen (stop for less than two weeks) \*Leukotriene antagonists (stop for less than a week) \* Nasal vasoconstrictors (one week)\*
- Acute bacterial rhinosinusitis, systemic hypertension, myocardial infarction (\<3 months), recent stroke (\<3 months), known arterial aneurysm, epilepsy treatment, drug allergy
- Inability to measure a change in flow resistance and intra nasal (nasal obstruction complete)
- History of anaphylaxis to the allergen tested
- Nasal surgery 6-8 weeks before the study
- Subject exclusion period (determined by a previous study or in progress)
- Unable to give informed about the information (subject in an emergency situation, difficulties in understanding the subject)
- Inability to understand the maneuvers of nasal provocation test
- Subject in safeguarding justice, under guardianship
- Pregnancy and lactation
Key Trial Info
Start Date :
January 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2012
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01485523
Start Date
January 1 2012
End Date
August 1 2012
Last Update
March 13 2013
Active Locations (1)
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1
Pole de pathologie thoracique.Unité d'allergologie, d'asthmologie et de pathologie respiratoire de l'environnement
Strasbourg, France, France, 67000