Status:
COMPLETED
Imaging Airway Liquid Absorption in Cystic Fibrosis
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
6+ years
Phase:
NA
Brief Summary
The investigators are developing a new nuclear medicine imaging technique for measuring liquid absorption in the airways that can be applied to screen new medications being developed to treat cystic f...
Detailed Description
The investigators have recently developed a novel aerosol-based imaging technique to detect changes in liquid absorption in the airways - a central pathophysiological process known to be important in ...
Eligibility Criteria
Inclusion
- Adult healthy control arm:
- subjects 18 years old or older without a diagnosis of lung disease.
- Pediatric CF arm:
- subjects 6-14 years with a diagnosis of cystic fibrosis as determined by sweat test or genotype
- subjects who are clinically stable as determined by the pediatrician co-investigator
- subjects must have a previously demonstrated ability to perform reproducible pulmonary function testing based on previous clinical visits.
- Females in all groups who are of child-bearing potential will need to have a negative urine pregnancy test.
Exclusion
- Adult healthy control arm:
- FEV1%p \< 80% of predicted
- nursing mother
- positive urine pregnancy test or unwilling to test
- cigarette smoker (regular smoking within 6 months of study).
- Pediatric CF arm:
- FEV1%p \< 40% of predicted
- nursing mother
- positive urine pregnancy test for females of childbearing potential
- unable or unwilling to comply with test procedure
- cigarette smoker (regular smoking within 6 months of study).
- Subjects unable to lie recumbent without moving for the 80 minute imaging period will be excluded.
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01486199
Start Date
October 1 2011
End Date
October 1 2014
Last Update
September 25 2017
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213