Status:
COMPLETED
Transcranial Direct Current Stimulation and Aphasia Language Therapy
Lead Sponsor:
Shirley Ryan AbilityLab
Collaborating Sponsors:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Nonfluent Aphasia
Stroke
Eligibility:
All Genders
21+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to evaluate the effectiveness of small amounts of electrical current, applied without surgery to the brain, in combination with speech-language treatment, on the language ...
Detailed Description
Stroke is the third leading cause of death and the most common cause of disability in the United States. According to the American Stroke Association, the prevalence of stroke in the U.S. is approxima...
Eligibility Criteria
Inclusion
- A single unilateral left-hemisphere infarct that is confirmed by CT scan or MRI
- Nonfluent aphasia, with a mean length of utterance of 0-4 words and an Aphasia Quotient score on the Western Aphasia Battery of 25-70
- Age 21 or older
- At least 6 months post-stroke
- Premorbidly right-handed, as determined by the Edinburgh Handedness Inventory
- Premorbidly literate in English
- Completed at least an eighth grade education
- Visual acuity no worse than 20/100 corrected in the better eye
- Auditory acuity, aided in the better ear, no worse than 30 dB HL on a pure tone hearing screening (conducted at 500, 1000, 2000, and 4000 Hz.)
Exclusion
- Any other neurological condition (other than cerebral vascular disease) that could potentially affect cognition or speech, such as Parkinson's Disease, Alzheimer's Dementia, traumatic brain injury
- Any significant psychiatric history prior to the stroke, such as severe major depression or psychotic disorder requiring hospitalization; subjects with mood disorders who are currently stable on treatment will be considered
- Active substance abuse
- Seizure disorder that precludes safe participation in this trial
- Absence of left hemisphere activation during two of the three fMRI tasks
- Presence of lesions that encompass premotor cortex from the Sylvian fissure to a point high on the convexity
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2016
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01486654
Start Date
March 1 2010
End Date
December 1 2016
Last Update
May 15 2017
Active Locations (1)
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1
Center for Aphasia Research & Treatment, Rehabilitation Institute of Chicago
Chicago, Illinois, United States, 60611