Status:
UNKNOWN
Proteomics & Glyco-Proteomic Analysis of Follicular Fluid
Lead Sponsor:
University of Cincinnati
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Polycystic Ovary Syndrome
Normal Volunteers
Eligibility:
FEMALE
18+ years
Brief Summary
To the best of the investigators knowledge, exhaustive characterization of the low and high abundant proteins and glyco-proteins of the Follicular Fluid (FF) has not yet been achieved. Such an analysi...
Detailed Description
In this study, we plan to utilize ultrasensitive mass spectrometry (MS) and other conventional proteomic approaches to identify the low and high abundant proteins present in human FF. Additionally, we...
Eligibility Criteria
Inclusion
- Inclusion criteria: Inclusion Criteria All
- Female patients undergoing controlled ovarian hyperstimulation (COH), transvaginal oocyte aspiration (TVA), and Saline Infused Sonography (SIS) with UL collection
- Age \<35 y/o at time of in vitro fertilization (IVF) cycle
- Normal ovarian function defined Day 3 Follicular Stimulating Hormone (FSH) \<8 pg/ml or Anti-Mullerian Hormone (≥ 1.0 ng/ml)
- Inclusion Criteria Controls:
- Female patients undergoing COH and TVA donating her oocytes
- Female patients undergoing COH and TVA for male factor infertility only (i.e. no female causes of infertility)
- Normal menstrual cycles
- Inclusion Criteria Lean PCOS:
- Diagnosis of PCOS by Rotterdam Criteria
- BMI ≤ 25 kg/m2 Inclusion Criteria Classic PCOS
- 1\. Diagnosis of PCOS by Rotterdam Criteria 2. BMI \> 30 kg/m2
- Exclusion criteria:
- Age ≥ 35 y/o
- Female partners with infertility associated diagnosis (i.e. tubal factor, cervical factor, endometriosis)
- Unexplained infertility
Exclusion
Key Trial Info
Start Date :
December 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2014
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01487486
Start Date
December 1 2011
End Date
January 1 2014
Last Update
December 7 2011
Active Locations (1)
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1
Center for Reproductive Health
Cincinnati, Ohio, United States, 45219