Status:
COMPLETED
Effect of Curcumin on Iron Metabolism in Healthy Volunteer
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Healthy Volunteers
Eligibility:
MALE
18-35 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine the impact of curcumin, administrated orally, on iron metabolism in healthy volunteers. Iron metabolism will be describe by hepcidin expression that the inves...
Eligibility Criteria
Inclusion
- Body mass index between 18 et 25 Kg/m²
- Non smoker
- No swallowing disorders
- Normal clinical exam
- Normal ECG
- Normal values for routine biological tests : serum iron, transferrin saturation,, hemogram ferritin, C Reactive Protein, AST, ALT, HDL and LDL cholesterol, triglycerides
- No C282Y mutation within the HFE gene
- Affiliation to social security
- Written informed consent obtained
Exclusion
- Chronic or evolutive disease
- Infection during the 7 days before each sequence
- Drug or alcohol (\>30g) abuse
- Current treatment
- Known food allergy
- stay at altitude (\> 1500m) in 2 months
- Positive serology for hepatitis B or C virus or HIV.
- Transfusion or blood donation during the last three months.
- Exclusion period on the healthy volunteer National File.
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2012
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT01489592
Start Date
October 1 2011
End Date
March 1 2012
Last Update
August 27 2025
Active Locations (1)
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1
Centre d'Investigation Clinique (CIC) , 2 rue Henri Le Guilloux , CHU Pontchaillou
Rennes, France, 35000