Status:

COMPLETED

Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Non-ST Elevation Myocardial Infarction

Lead Sponsor:

Oslo University Hospital

Collaborating Sponsors:

St. Olavs Hospital

South-Eastern Norway Regional Health Authority

Conditions:

Non-ST Elevation Myocardial Infarction

Eligibility:

All Genders

18-80 years

Phase:

PHASE2

Brief Summary

Acute coronary syndromes (ACS) are still associated with high morbidity and mortality, despite several improvements in their management. This may indicate that important pathogenic mechanisms contribu...

Eligibility Criteria

Inclusion

  • NSTEMI (ESC Type 1)
  • Age 18-80 years
  • Troponin T \>/= 30 ng/ml
  • Informed consent to participation

Exclusion

  • STEMI
  • Known cardiac disease, except coronary disease (cardiomyopathy, heart failure with known EF \< 45%, severe valvular heart disease attending regular follow-up, recent PCI/ACB (\< 3 months))
  • Hemodynamic and/or respiratory instability
  • Cardiac arrest in acute phase
  • Concurrent condition affecting/potentially affecting CRP (infection, malignancy, autoimmune disease)
  • Recent major surgery (\< 3 months)
  • Recent/concurrent immunosuppressant treatment (\< 2 weeks, except NSAIDs)
  • Severe renal failure (eGFR \< 30 ml/min)
  • Pregnancy
  • Contraindications to any study investigations and/or medication.
  • Expected non-adherence to study protocol

Key Trial Info

Start Date :

August 1 2011

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

April 1 2014

Estimated Enrollment :

120 Patients enrolled

Trial Details

Trial ID

NCT01491074

Start Date

August 1 2011

End Date

April 1 2014

Last Update

May 19 2014

Active Locations (2)

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Page 1 of 1 (2 locations)

1

Oslo University Hospital

Oslo, Oslo County, Norway, 0424

2

St Olavs Hospital

Trondheim, Sør-Trøndelag, Norway, 7006