Status:
COMPLETED
Abnormal Movements, Cerebellum and Sensorimotor : Oculomotor Study
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Healthy
Dystonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Dystonia is a movement disorder characterized by involuntary, sustained, often repetitive muscle contractions of opposite muscles that lead to abnormal twisting movements or odd postures. Essential tr...
Detailed Description
Dystonia is a movement disorder characterized by involuntary, sustained, often repetitive muscle contractions of opposite muscles that lead to abnormal twisting movements or odd postures. Essential tr...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Age ≥18 years
- -normal cognitive functions (\>24y)
- Normal clinical examination of ocular mobility, visualization of the target
- No drug potentially able to modify and to influence the data: anti-depressants, neuroleptics, anti-emetics, amphetamines, anti myoclonic/dystonic drugs, alcohol, dopaminergic drug, antiepileptic.
- Dystonia or essential tremor or Parkinson: diagnostic made by a neurologist
- For DYT11: mutation in SGCE gene.
- For dystonia: No secondary dystonia
- For Parkinson : UPDRS\<28
- No other neurological disorder
- For the patient having deep brain stimulation:
- Duration of stimulation\> 6 months
- Cerebral imagery post operation made
- Stimulation parameter stable since 3 months at least.
- Usual stop of the stimulation during the night
- Exclusion criteria:
- Uncontrollable medical problems not related to M-D
- Current active psychiatric disorder
- Intake during the last 3 days of drugs potentially able to modify and to influence the data: anti-depressants, neuroleptics, anti-emetics, amphetamines, anti myoclonic/dystonic drugs, alcohol, dopaminergic drug
- Subjects legally protected.
- Subjects who are not enrolled at social security.
Exclusion
Key Trial Info
Start Date :
March 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT01495897
Start Date
March 1 2011
End Date
March 1 2014
Last Update
September 4 2025
Active Locations (1)
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1
: Fédération des Maladies du Système Nerveux
Paris, France, 75013