Status:
COMPLETED
Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.
Lead Sponsor:
Hospital Son Llatzer
Conditions:
Pulmonary Disease, Chronic Obstructive
Obesity Hypoventilation Syndrome
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to analyze whether the treatment of metabolic alkalosis with acetazolamide in intubated patients with chronic obstructive pulmonary disease (COPD) or with obesity hypovent...
Detailed Description
Metabolic alkalosis (MA) may reduce central respiratory drive, cardiac output and worsen oxygenation, leading to a delay in weaning from MV. Acetazolamide is a carbonic anhydrase inhibitor that is abl...
Eligibility Criteria
Inclusion
- Patients with COPD or obesity hypoventilation syndrome on invasive mechanical ventilation during less than 72 h with metabolic alkalosis, defined as a pH \> 7.35 and actual bicarbonate \> 28 mmol/L, and with potassium plasmatic levels \>= 4 mEq/L.
Exclusion
- Postoperative patients.
- Previous psychiatric disease.
- Epilepsy.
- Pregnancy.
- Hepatic cirrhosis.
- Sulfonamide or acetazolamide allergy.
- Plasmatic creatinine \> 2.5 mg/dL or creatinine clearance \< 20 mL/min or continuous renal replacement techniques.
- Intolerance to enteral feeding.
- Administration in the previous 72 h of bicarbonate or acetazolamide.
- Terminal disease.
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2015
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT01499485
Start Date
November 1 2011
End Date
February 1 2015
Last Update
March 17 2015
Active Locations (8)
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1
Hospital de Manacor
Manacor, Balearic Islands, Spain, 07500
2
Hospital Son Espases
Palma de Mallorca, Balearic Islands, Spain, 07010
3
Hospital Son Llàtzer
Palma de Mallorca, Balearic Islands, Spain, 07198
4
Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain, 08025