Status:
TERMINATED
Non Invasive Positive Pressure Ventilation for Prevention of Acute Chest Syndrome in Sickle Cell Disease
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Sickle Cell-hemoglobin SS Disease
Vaso-occlusive Crisis
Eligibility:
All Genders
6-20 years
Phase:
NA
Brief Summary
Acute chest syndrome is a severe respiratory complication of sickle cell disease. The standard prevention of this dangerous complication is spirometry in wich patient is required to take deep breaths...
Detailed Description
Acute chest syndrome is a severe complication of sickle cell disease. Several factors can contribute to this complication including infections, vaso-occlusive crisis, important pain that may give shor...
Eligibility Criteria
Inclusion
- Patient with SS or S-Beta sickle cell disease aged more than 6 years old and less then 20 years old
- Hospitalised since less then 24 hours for severe vaso-occlusive crisis (either peripheric localisation or thoracic crisis) with morphinic requirements according to local pain management protocol
- With a signed informed consent from the patient or his legal representative if the patient is under 18 years old
- Benefiting of the French social security system
Exclusion
- Patient that has already participated in the study
- Oxygen requirements, pneumonia, acute chest syndrome or other condition necessitating non invasive ventilation on admission
- No understanding of spirometry or ventilation techniques
- Other condition that forbid the use of non invasive ventilation or spirometry as defined by french consensus conference (2006) on non invasive ventilation
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT01501643
Start Date
November 1 2011
End Date
April 1 2015
Last Update
April 10 2015
Active Locations (1)
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1
Hôpital Necker - Enfants Malades Hospital
Paris, France, 75015