Status:
COMPLETED
Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
Forest Laboratories
Conditions:
Hypertension
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduc...
Detailed Description
In 32 untreated stage 1 hypertensive subjects, the investigators will measure blood pressure; noninvasive cardiac output by thoracic electrical bioimpedance (Bioz, Cardio Dynamics); forearm mediated v...
Eligibility Criteria
Inclusion
- Men and women with stage I primary untreated hypertension (BP between 140-159/90-99 mmHg)
- Age 18-65
Exclusion
- Congestive heart failure
- Coronary artery disease
- Left ventricular hypertrophy by echocardiography or ECG
- History of stroke
- Average blood pressure \>159/99 mmHg
- Bradycardia with a resting heart rate \<55 bpm
- Chronic kidney disease with a serum creatinine \> 1.4 mg/dL
- Asthma or chronic obstructive pulmonary disease
- Women who are pregnant or planning to become pregnant
- Hypersensitivity to beta blockers, hydrochlorothiazide, or Definity
- Any history of substance abuse (other than tobacco)
- Concomitant drug treatment which raises endogenous nitric oxide levels, including nitrates or phosphodiesterase V inhibitors (Viagra, Levitra)
- History of symptomatic bradycardia or heart block
- Patients with Right-to-left, bidirectional, or transient right-to-left cardiac shunts
- Hypersensitivity to perflutren, blood, blood products or albumin.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT01501929
Start Date
August 1 2010
End Date
December 1 2015
Last Update
November 6 2018
Active Locations (1)
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1
UT Southwestern Medical Center
Dallas, Texas, United States, 75390-8586