Status:
COMPLETED
Efficacy of Enteral Glutamine Supplementation in Patients With Predicted Severe Acute Pancreatitis- A Double-Blinded Randomized Controlled Trial
Lead Sponsor:
Asian Institute of Gastroenterology, India
Conditions:
Acute Pancreatitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute pancreatitis (AP) is a potentially serious illness characterized by inflammation of the pancreas with variable involvement of peri-pancreatic tissues and/ or remote organ systems. AP is hyper ca...
Detailed Description
Acute pancreatitis (AP) is a potentially serious illness characterized by inflammation of the pancreas with variable involvement of peri-pancreatic tissues and/ or remote organ systems. AP contributes...
Eligibility Criteria
Inclusion
- Patients over the age 18.
- Patient admitted within 72hrs of onset of abdominal pain for over 24hr with raised (\>3- fold) serum lipase/amylase on admission.
- Marshall Score of ≥ 2 in any one organ, excluding the liver component
- Pancreatic necrosis \>30% on Computed tomography (CT) scan or a modified CT severity index of ≥6.
- Apache II score ≥8.
- BUN at admission of \>20mg/dL or an BUN elevation of \>5mg/dL within 48hrs of admission.
Exclusion
- Patients with chronic pancreatitis and pancreatic insufficiency requiring pancreatic enzyme supplements.
- Pre-existing chronic renal insufficiency requiring hemodialysis or peritoneal dialysis.
- Patients with ARF.
- Pre-existing end-stage liver disease with ascites, coagulopathy and encephalopathy.
- Pancreatic cancer.
- Current somatostatin or corticosteroid therapy.
- Any form of artificial feeding since commencement of acute pancreatitis symptoms.
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01503320
Start Date
January 1 2012
End Date
December 1 2014
Last Update
June 8 2015
Active Locations (1)
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1
Asian Institute of Gastroenterology
Hyderabad, Andhra Pradesh, India, 500082