Status:
TERMINATED
Red Blood Cell Transfusion in Patients With Coronary Artery Disease (CAD)
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborating Sponsors:
American Heart Association
Conditions:
Acute Coronary Syndrome
Anemia
Eligibility:
All Genders
18-100 years
Phase:
PHASE1
PHASE2
Brief Summary
Patients with a low blood count (anemia) with stable or unstable coronary artery disease consistently show worse clinical outcomes. It is unclear whether this association is confounded since anemic pa...
Detailed Description
Adverse clinical outcomes are reduced when critically ill patients are only transfused if their hematocrit drops below 21%: Hematocrit (HCT) is a measure of the severity of anemia. A HCT is considered...
Eligibility Criteria
Inclusion
- ACS as defined by a patient who has cardiac chest discomfort and a troponin (cTnT) elevation of greater than 0.1 ng/mL.
- Pt. who is s/p CABG
- Patients with chronic coronary artery disease will be recruited as defined as past history of myocardial infarction, percutaneous coronary intervention, CABG, or history of coronary artery disease documented in the medical record.
- Anemia as defined by HCT between 21%-30%.
Exclusion
- Patients with stage III/IV heart failure
- Patients who are actively bleeding requiring immediate transfusion.
- Pregnant patients will be excluded.
- Patients taking sildenafil (Viagra) or other drugs like it, such as vardenafil (Levitra), or tadalafil (Cialis) within 48 hours before the study.
- Patients on iv nitroglycerine infusion.
- Patients who present with ACS or CABG surgery and who are hemodynamically unstable or require immediate revascularization.
- Patients who have received a blood transfusion 24 hours prior to the start of the study.
- Patients with a HCT of \< 21% and those that have chest tube drainage greater then 30 mL/h will be excluded.
Key Trial Info
Start Date :
February 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2017
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01504945
Start Date
February 1 2010
End Date
December 1 2017
Last Update
February 23 2018
Active Locations (1)
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1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215