Status:
COMPLETED
Biomarkers for Noninvasive Assessment of Human Hydration
Lead Sponsor:
Gaia Medical Institute
Collaborating Sponsors:
U.S. Army Medical Research and Development Command
Conditions:
Dehydration
Eligibility:
All Genders
18-40 years
Brief Summary
Low levels of dehydration (the loss of body water corresponding to 2% of the body weight), deteriorate physical and cognitive performance and may also be linked to a number of chronic diseases. The st...
Detailed Description
Dehydration, or the loss of body water, is a common health problem during military operations, athletic events and illness, particularly in children and the elderly. Warfighters frequently become dehy...
Eligibility Criteria
Inclusion
- Signed Informed Consent Form
- Males and females between 18-40, healthy and aerobically fit determined by VO2max test. Minimum 45 ml/kg/min for males and 40 ml/kg/min for females
- Willing to stop drinking any alcoholic beverages, taking all supplements and limit medications to those approved for the study
- No heart conditions assessed by medical history and passing the PAR-Q
- Complete and pass medical exam
Exclusion
- Positive response to any PAR-Q questions
- Physical problems/injuries associated with walking or cycling
- VO2Max below 45 ml/kg/min for men and 40 ml/kg/min for women
- Allergy to sulfa drugs
- Existing heart and or lung conditions
- Pregnant or breastfeeding
- History of heat illness or heat injury
- History of kidney stones or chronic renal problems
- History of orthostatic hypotension, diabetes or gout
- Taking certain medications: NSAIDS \[anti-inflammatory/pain medications\], digitalis \[a type of heart medication\], lithium and anti-depressants \[medications used in psychiatry\], anti-hypertensives \[medications to lower the blood pressure\], anti-fungals \[medications used to treat infectious type of mold\], supplements or anti-cholinergic drugs)
- Taking any supplements, particularly creatine in 24 hours before the start of the study, or during the study
- Alcohol consumption 24 hours before the start of the study, or during the study
- Incapable to give informed consent
- Anemia
Key Trial Info
Start Date :
October 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT01507129
Start Date
October 1 2010
End Date
August 1 2012
Last Update
August 15 2012
Active Locations (1)
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1
Clinical and Translational Research Institute
San Diego, California, United States, 92037