Status:
COMPLETED
Analgesic Effect of Gabapentin in Total Knee Arthroplasty (TKA)
Lead Sponsor:
Hvidovre University Hospital
Collaborating Sponsors:
Lundbeck Foundation
Conditions:
Postoperative Pain
Postoperative Sedation
Eligibility:
All Genders
50-85 years
Phase:
PHASE4
Brief Summary
Pain is a major problem after TKA. Gabapentin may reduce acute postoperative pain. The investigators therefore investigate the effect of Gabapentin as a perioperative analgesic.
Detailed Description
Pain is a major problem after TKA. Studies indicate that Gabapentin may reduce acute postoperative pain. However, the optimal dose is unknown and there is constant controversy on analgesic versus side...
Eligibility Criteria
Inclusion
- Primary, unilateral total knee arthroplasty (TKA)
- Age 50-85 years
- Ethnic Danes
Exclusion
- Treatment with gabapentins, systemic glucocorticoids, opioids, anxiolytic agents, antiepileptics or antidepressive agents (last 4 weeks)
- History of depression or mania
- History of alcohol or drug abuse
- History of malignancy
- History of epilepsia
- BMI \> 40
- Disease affecting central or peripheral nerve function
- History of dementia
- History of renal insufficiency
- Allergy to Gabapentin
- Women with menstruation (last 2 years)
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT01507363
Start Date
January 1 2012
End Date
November 1 2013
Last Update
April 11 2014
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Dep. of ortopedic surgery, Aalborg Sygehus
Aalborg, Aalborg, Denmark, 9000
2
Dep. of ortopedic surgery, Esbjerg Sygehus
Esbjerg, Esbjerg, Denmark, 6700
3
Dep. of anesthesiology and ortopedic surgery Hvidovre Hospital
Copenhagen, Hvidovre, Denmark