Status:
TERMINATED
Profile of Soluble and Cellular Biomarkers and of Functional Imaging During Antiangiogenic Therapies in Cancer Patients
Lead Sponsor:
Medical University Innsbruck
Conditions:
Hepatocellular Cancer
Non-small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Brief Summary
Tumour angiogenesis has been identified to play a critical role in tumour growth and this knowledge has led to the identification of new targets for cancer therapy. Multiple angiogenic factors are inv...
Eligibility Criteria
Inclusion
- Age over 18 years
- Patients with HCC, NSCLC, RCC or CRC treated with an approved antiangiogenic drug (bevacizumab, sorafenib, sunitinib)\*
- Patients with at least one measurable lesion. Lesions must be measurable by CT-scan or MRI (Magnetic resonance imaging) according to Response Evaluation Criteria in Solid Tumours (RECIST)
Exclusion
- Pregnant or breast-feeding patients. Women of childbearing potential must have a negative pregnancy test performed within 7 days of the start of treatment. Both men and women enrolled in this trial must use adequate birth control measures during the course of the trial. The definition of effective contraception will be based on the judgment of the principal investigator or a designated associate.
- Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results
- Known or suspected allergy to the investigational agent or any agent given in association with this trial -\_\> allergy
- MRI contraindications: implants (pacemaker)
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01507740
Start Date
July 1 2009
End Date
October 1 2014
Last Update
April 29 2015
Active Locations (1)
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1
University Hospital Innsbruck, Internal Medicine V, Hematology Oncology
Innsbruck, Austria, A-6020