Status:
UNKNOWN
Diesel Exhaust and Vascular Function
Lead Sponsor:
University of Washington
Collaborating Sponsors:
National Institute of Environmental Health Sciences (NIEHS)
Environmental Protection Agency (EPA)
Conditions:
Cardiovascular Effects
Eligibility:
All Genders
18-49 years
Phase:
NA
Brief Summary
Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function. To examine role of adrenergic system a trial of alph...
Eligibility Criteria
Inclusion
- healthy without chronic illness
- Body Mass Index 18.5 - 26.0
- tolerates 2 mg terazosin dose without unacceptable symptoms
- able to return for four exposure sessions
Exclusion
- any chronic disease
- tobacco user
- asthma
- elevated cholesterol
- obesity
- hypertension
- diabetes
- any chronic cardiovascular or pulmonary disease
- pregnancy or unwillingness to use effective contraception, if female
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01508637
Start Date
January 1 2012
End Date
December 1 2015
Last Update
August 3 2015
Active Locations (1)
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1
University of Washington Medical Center
Seattle, Washington, United States, 98195