Status:
COMPLETED
Study of Metabolic and Haemodynamic Effects of Metformin and Glimepiride in Patients With Type 2 Diabetes Mellitus
Lead Sponsor:
University of Sao Paulo
Conditions:
Type 2 Diabetes
Eligibility:
All Genders
40-70 years
Phase:
PHASE4
Brief Summary
Aim: The purpose of this study is to compare the effects of glimepiride(G) and metformin(M) on vascular reactivity, haemostatic factors and glucose and lipid profile in patients with type 2 diabetes....
Detailed Description
Measurements were be made at fasting
Eligibility Criteria
Inclusion
- type 2 diabetes patients with fasting glucose values \>7.78 mmol/L and/or glycated hemoglobin exceeding 1.0% or more the normal range (4-8.5%) after 2 or more months of a diet therapy
Exclusion
- any severe concomitant illness
- nephropathy (serum creatinine \>1.6 mg/dL and microalbuminuria)
- uncontrolled hypertension (BP \>190x120 mmHg)
- stroke
- peripheral vascular disease
- marked dyslipidemia (total cholesterol\>6.5mM/L and triglycerides levels \>2.8mM/L)
- coagulopathy
- proliferative retinopathy and use of hypolipemic and anticoagulant medications or autonomic neuropathy
- assessed by blood pressure response to standing
- beat-to -beat heart rate variation
- Valsalva maneuver and handgrip test.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01509001
Start Date
January 1 2011
End Date
January 1 2012
Last Update
January 16 2012
Active Locations (1)
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1
Clinical Hospital of São Paulo Medical School
São Paulo, São Paulo, Brazil