Status:
COMPLETED
Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest
Lead Sponsor:
University of Washington
Conditions:
Cardiac Arrest
Eligibility:
All Genders
65+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to assess the feasibility of hemofiltration in patients resuscitated from cardiac arrest. Cardiac arrest is the loss of mechanical activity of the heart including the loss...
Detailed Description
Patients resuscitated from out-of-hospital cardiac arrest will be randomly allocated to one of three groups; Standard of care: Initiate standard of post-resuscitative care including a triple lumen cat...
Eligibility Criteria
Inclusion
- adults
- restoration of spontaneous circulation sustained to hospital arrival after OOHCA with any first recorded rhythm
- aged \>=65 years
- less than 1 h from call to 911 until emergency department arrival
- less than 6 h from arrival until randomization
- informed consent provided by legally-authorized representative
Exclusion
- do not attempt resuscitation orders; known end-stage terminal illness pre-arrest; major pre-arrest neurological dysfunction; another reason to be comatose (e.g. drug overdose)
- chronic steroid use
- non-English speaking LAR
- previous enrollment in the trial
- blunt, penetrating, or burn-related injury; exsanguination; drowning, electrocution or strangulation
- known pregnancy
- known prisoner
- weight \> 100 kg
- persistent (i.e. 30 minutes) SBP\< 80 mmHg despite pressors; refractory ventricular arrhythmias; severe bradycardia without a pacemaker
- thrombocytopenia (i.e. \< 50,000/microL) or coagulopathy (i.e. INR \> 1.5) or inferior vena cava filter in situ
- known cirrhosis
- serum ionized calcium \< 2.2 mmol/L serum lactate \> 6 mmol/L
- obeying verbal commands
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT01509040
Start Date
January 1 2012
End Date
June 1 2014
Last Update
June 9 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Harborview Medical Center
Seattle, Washington, United States, 98040