Status:
UNKNOWN
Mineralocorticoid Receptor Antagonist and Kidney Allograft Histology
Lead Sponsor:
Clinical Hospital Merkur
Conditions:
Kidney Failure, Chronic
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
Chronic allograft nephropathy is one of dominant causes of long term kidney transplant failure. Its main histological determinant is interstitial fibrosis and tubular atrophy. Mechanisms of these chan...
Detailed Description
Chronic allograft nephropathy (CAN) is the main cause of long term kidney transplant failure. Its main histological determinant is interstitial fibrosis and tubular atrophy, but mechanisms of these ch...
Eligibility Criteria
Inclusion
- kidney and kidney-pancreas recipients, including patients with delayed graft function ( DGF). DGF will be defined as the dialysis need in first 7 days after transplantation
Exclusion
- Baseline plasma potassium level above 5.1 µmol/L
- Patients on ACE inhibitor or ARB-s therapy
- Patients with eGFR \< 30 ml/min (estimated by MDRD formula)
- Patents younger than 18 yr
- Patients with hypersensitivity to spironolacton
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2014
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01510795
Start Date
January 1 2012
End Date
January 1 2014
Last Update
January 18 2012
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.