Exploring Learning and Unlearning of Fear

Status:

WITHDRAWN

Exploring Learning and Unlearning of Fear

Lead Sponsor:

Universitaire Ziekenhuizen KU Leuven

Conditions:

Healthy Individuals

Eligibility:

All Genders

18-40 years

Phase:

Brief Summary

The present study investigates the effect of d-cycloserine on learning and unlearning of fear in healthy humans and its underlying effect on the amygdala. As a second objective, the effect of genotyp...

Detailed Description

A growing body of evidence suggests that the extinction of fear is mediated by the N-methyl-D-aspartate (NMDA) receptor activity in the basolateral amygdala. Intra-amygdala infusions of antagonists of...

Eligibility Criteria

Inclusion

No axis I diagnosis compatible with the DSM-IV by means of a structured diagnostic interview
Right-handed

Exclusion

Current psychopharmacological or psychological treatment.
The presence of a physical/medical condition that may interfere with the study.
A contraindication for the use of DCS
Pacemaker, medication pump (such as insulin pump), hearing aid, removable prosthodontics
Metal in or on body (such as acupuncture needles, artificial limbs, stents, metal splints, clips, implanted electrodes, tattoos, or piercings)

Key Trial Info

Start Date :

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

Estimated Enrollment :

Patients enrolled

Trial Details

Trial ID

NCT01512316

Last Update

January 31 2023

Active Locations (1)

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