Status:
COMPLETED
Non-invasive Quantification of Liver Iron With MRI
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Iron Overload
Hemosiderosis
Eligibility:
All Genders
10+ years
Brief Summary
The purpose of this study is to validate magnetic resonance imaging as a biomarker of hepatic iron concentration (HIC). Excessive accumulation of iron in the body is highly toxic, specifically in the ...
Detailed Description
Excessive accumulation of iron in the body can result from abnormal intestinal absorption in hereditary hemochromatosis or repeated intravenous blood transfusions (ie: transfusional hemosiderosis). Ex...
Eligibility Criteria
Inclusion
- Controls: 18 years or older with no known history of iron overload or liver disease.
- Patients: 10 years or older with known or suspected iron overload
Exclusion
- Patients with contraindications to MRI (eg. pacemaker, contraindicated metallic implants, claustrophobia, etc) and pregnant females (as determined by self-report during MRI safety screening) will be excluded.
- For control subjects, those with known liver disease will be excluded.
Key Trial Info
Start Date :
January 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01516853
Start Date
January 1 2012
End Date
June 1 2015
Last Update
December 6 2019
Active Locations (1)
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1
Wisconsin Institutes for Medical Research
Madison, Wisconsin, United States, 53705