Status:
COMPLETED
Studying Motor Neuron Tests
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Healthy Subjects
Magnetic Resonance Imaging
Eligibility:
All Genders
35+ years
Brief Summary
Background: \- People with motor neuron disorders have changes in the parts of the brain that control movement. Some tests that are currently used to study these changes are magnetic resonance imagin...
Detailed Description
Objective The objective of the protocol is to determine the test-retest reliability of imaging techniques that measure the structural and functional integrity of the motor cortex in healthy subjects....
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy adults aged 35 and older
- No history of a neurological disorder
- Able to give informed consent
- EXCLUSION CRITERIA:
- Treatment within the preceding week with medications that affect neuronal excitability, such as antidepressants, sedatives, and drugs for epilepsy or migraine.
- Change in blood pressure medications within the preceding week.
- Metal in the body such as pacemakers, implanted pumps or other implanted electronic devices, some types of dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner or shrapnel fragments.
- Pregnancy. Women of childbearing potential will undergo urine pregnancy testing before MRI scanning.
- Fear of confined spaces.
- Serious medical illness.
- Employees or staff in the investigator's section.
Exclusion
Key Trial Info
Start Date :
February 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 25 2020
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT01517087
Start Date
February 1 2012
End Date
November 25 2020
Last Update
March 12 2021
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892