Status:
COMPLETED
Alfentanil and the Elimination of Sympathetic Responses to Tracheal Intubation During Rapid Sequence Induction of Anesthesia: A Probability-based Approach
Lead Sponsor:
Oslo University Hospital
Collaborating Sponsors:
University Hospital, Aker
Conditions:
Anesthesia Intubation Complication
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
Induction of anesthesia: After 3 minutes pre-oxygenation with 100% oxygen, a blinded dose alfentanil (0,10,20,30,40,50 or 60 µg/kg, followed by thiopental 4 mg/kg and rocuronium 0.6 mg/kg will be adm...
Detailed Description
Introduction: Autonomic responses (blood pressure and heart rate increases) secondary to tracheal intubation are probably not harmful to healthy individuals(1). However, in certain groups of patients...
Eligibility Criteria
Inclusion
- ASA I and II patients and admitted for elective surgery.
- Aged 18-55 years
- Written informed consent
Exclusion
- Body Mass Index (BMI) \> 28 Kg/m²
- Patients with known allergy to study drug
- Patients with known porphyria
- Neuromuscular disease or undergoing treatment with drugs known to interfere with neuromuscular transmission.
- Mallampati class \> 2airway anatomy, or anticipated difficulty with mask ventilation or tracheal intubation.
- Neuromuscular disease
- Pulmonary disease
- Cardiovascular disease.
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT01518608
Start Date
September 1 2009
End Date
October 1 2011
Last Update
January 26 2012
Active Locations (2)
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1
Oslo University Hospital/ Aker
Oslo, Akershus, Norway, 0514
2
Oslo University Hospital / Aker
Oslo, Norway, 0514