Status:
COMPLETED
Reducing Radioisotope Dose: the Half-Dose CZT Study
Lead Sponsor:
S.M.Chang, MD
Collaborating Sponsors:
The Methodist Hospital Research Institute
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
This is a pilot study to see whether cardiac imaging can be performed using half the standard dose of radioisotope.
Detailed Description
The aim of this study is to compare the image quality of the half radioisotope dose scans obtained using a CZT (cadmium zinc telluride) camera with scans acquired using a standard of care imaging prot...
Eligibility Criteria
Inclusion
- ≥ 18 years of age and referred for a clinically-indicated stress SPECT MPI study
- suspected or known coronary artery disease
- written informed consent
Exclusion
- Evidence of a normal baseline scan after at least 50% of the protocol acquired baseline scans have been interpreted as being normal
- Participation in another investigational study within the preceding month
- Pregnant and/or breast-feeding female
- ECG evidence of left bundle branch block or paced rhythm
- Evidence of non-ischemic cardiomyopathy
- Presence of hypertrophic cardiomyopathy and/or severe valvular heart disease
- Severe claustrophobia or inability to lie flat for 20 minutes (the anticipated amount of time to complete the procedure)
- Known allergy to technetium-99m
- Potential contraindications to regadenoson use, due to severe lung disease; severe bradycardia (heart rate \< 40 beats/min); second- or third degree atrioventricular heart block; sick sinus syndrome; long QT syndrome; severe hypotension; or decompensated heart failure.
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 16 2016
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT01518777
Start Date
January 1 2012
End Date
December 16 2016
Last Update
September 6 2019
Active Locations (1)
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1
Houston Methodist Hospital
Houston, Texas, United States, 77030