Status:
COMPLETED
Interaction Between a Calcimimetic Agent and the Renin Angiotensine Aldosterone System
Lead Sponsor:
Centre Hospitalier Universitaire Vaudois
Collaborating Sponsors:
Swiss National Science Foundation
Conditions:
Relationship Between Calcimimetic and the RAAS
Eligibility:
MALE
18-45 years
Phase:
NA
Brief Summary
The aim of this study is to evaluate, in healthy volunteers, the acute modulating effect of cinacalcet on the RAAS, the effect of furosemide on parathyroid secretion of PTH and the interaction between...
Detailed Description
The clinical trial will be monocentric (Service of Nephrology and Hypertension at CHUV, Lausanne) and will include 24 patients. The volunteers will get involved after inclusion (Inclusion Visit) in a ...
Eligibility Criteria
Inclusion
- Healthy subject
- Male
- Age \> 18 and \< 45 years old
- Caucasian
- Non-smoker
- BMI \>18 and \< 25 Kg/m2
- Normal clinical examination
- ECG normal, 12 leads
- Systolic arterial pressure (SBP) ≥100 ≤ 139 mmHg and diastolic arterial pressure (DBP) ≥50 ≤ 89 mmHg (after 5 minutes lying down, 3 measurements at 2-minute intervals; Omron machine; left arm)
- Heart rate (HR) ≥ 45 ≤ 90 beats/min
- Subject capable of understanding the written information and the written consent form.
- Subject must have given written, dated and signed consent before starting any trial procedure.
Exclusion
- • Female
- Age \< 18 or \> 45 years old
- Electrolyte disturbances, defined as any sodium, potassium, total or ionized calcium, phosphate or magnesium value outside of the laboratory's reference values (at the Inclusion Visit).
- Seropositive for HIV, HBV or HCV (at the Inclusion Visit).
- Positive detection of drugs in urine (opiates, cannabinoids, cocaine, benzodiazepines, amphetamines or barbiturates) (at the Inclusion Visit).
- Fall in SBP \> or DBP \> 10 mmHg after standing for 1 minute or any clinical manifestation of postural hypotension (at the Inclusion Visit).
- Any history of diseases or clinically significant conditions which may be gastrointestinal (such as gastritis or gastric ulcer), respiratory, psychiatric, neurological (medical history of convulsions), renal, hepatic or cardiac or other diseases/conditions or abnormal physical signs which may interfere with the study's objectives. The investigator may disqualify any subject for a valid medical or psychiatric reason.
- Ongoing involvement or in the 60 days prior to the Inclusion Visit in another research study.
- Chronic use of any medication (prescribed or not) during the 4 weeks prior to the Inclusion Visit (only the use of medications such as paracetamol for headaches will be tolerated at the lowest dose possible.
- Use of any medication known as CYP P450 3A4 inhibitors during the 12 weeks prior to the Inclusion Visit (amiodarone, diltiazem, verapamil, ketoconazole, itraconazole, voriconazole, posaconazole, fluconazole, miconazol, ritonavir, nelfinavir, amprenavir, indinavir, atazanavir, erythromycin, clarithromycin, josamycin, telithromycin)
- Donation of blood, plasma and/or marrow in the 3 months prior to the Inclusion Visit
- Medical history of dependence on drugs or alcohol abuse as defined by the DSM IVR, criteria for diagnosing drug and alcohol abuse and dependence on drugs.
- Medical history of intolerant reactions to cinacalcet or furosemide (or derivatives of sulfamides)
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT01519037
Start Date
January 1 2012
End Date
June 1 2014
Last Update
March 5 2020
Active Locations (1)
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1
CHUV, service de néphrologie/hypertension
Lausanne, Canton of Vaud, Switzerland, 1011