Status:
COMPLETED
Ascending Multiple-Dose Study to Evaluate VIA-3196 in Healthy Subjects
Lead Sponsor:
Madrigal Pharmaceuticals, Inc.
Conditions:
Drug Safety
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
This is a single-center, randomized, double-blind, placebo-controlled, ascending multiple-dose study of VIA-3196 to evaluate the Safety, Pharmacokinetics and Pharmacodynamics of VIA-3196 in Healthy Su...
Eligibility Criteria
Inclusion
- The subject must be willing and able to provide written informed consent.
- Healthy, non-smoking, males and females between the ages of 18 and 55 years of age (inclusive).
- If female, the subject is of non-child bearing potential (i.e., surgically \[bilateral oophorectomy, hysterectomy, or tubal ligation\] or naturally sterile \[\>12 consecutive months without menses\]). Verify by FSH at screening as appropriate.
- Body weight \> 50 kg and BMI between 18 and 30 kg/m2 (inclusive).
- LDL cholesterol ≥ 110mg/dL.
Exclusion
- History of thyroid disorder or abnormal thyroid function tests at screening. Repeat testing is allowed once at the discretion of the Investigator. - History of unexplained syncope.
- History of hepatobiliary disease; or AST, ALT or direct bilirubin greater than the upper limit of reference range at screening.
- Positive screening test for HIV antibody, Hepatitis B surface antigen or Hepatitis C antibody.
- Abnormal screening ECG: including machine-read QTc \>450 msec (confirmed by manual over read), QRS \>110 msec, intermittent bundle branch block, frequent premature atrial or premature ventricular contractions, or any rhythm other than normal sinus rhythm which is interpreted by the Investigator to be clinically significant.
- History of sensitivity to a similar study drug (e.g., Karo Bio KB2115 or Metabasis MB7811), or a history of important drug or other allergy (except for untreated, asymptomatic seasonal allergies at time of dosing) unless deemed not clinically significant by the Investigator.
- History of sensitivity to thyroid medication.
- History of asthma, or intolerance to beta-blockers.
- Use of acetaminophen within 7 days before dosing and throughout the study.
- History of regular use of tobacco or nicotine containing products within the past 6 months.
- Positive urine drug screen or alcohol test at screening or Day -1.
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT01519531
Start Date
January 1 2012
End Date
November 1 2012
Last Update
December 6 2012
Active Locations (1)
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1
PRACS Institute (formerly Cetero Research)
Fargo, North Dakota, United States, 58104