Status:
COMPLETED
Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension
Lead Sponsor:
Centre Hospitalier Universitaire Vaudois
Conditions:
Hypertension
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The goal of this project is to evaluate the chronic effect (8 weeks) of RASILEZ 300mg (aliskiren) on renal tissue oxygenation in patients with stage 1-2 hypertension, and to compare the chronic effect...
Detailed Description
36 patients with arterial hypertension stage 1-2 (blood pressure: 140/90 and 180/110 mm Hg) will be included in this study and randomized to two groups of 18 patients each: one group will receive RASI...
Eligibility Criteria
Inclusion
- Tolerance to study drugs
- Age \> 18 years
- Arteria hypertension stage 1-2 (blood pressure: 140/90 and 180/110 mm Hg)
- Normal renal function
- Availability to give informed consent
Exclusion
- Intolerance to study drugs
- Renal artery stenosis
- Hyperkalaemia \> 5.0 mmol/l
- Contra-indications to the use of PAH, inulin or Lithium
- Asthma
- Pychiatric illness
- No estimated easy vascular venous access for placement of two peripherical venous catheters in forearms
- Contra-indication to MRI-imaging: Claustrophobia or Pacemaker or other implanted metal device
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01519635
Start Date
October 1 2011
End Date
October 1 2014
Last Update
March 17 2020
Active Locations (1)
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1
Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, Switzerland, 1004