Status:
COMPLETED
TAKO-TSUBO Cardiomyopathy and Genetic
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Fédération Française de Cardiologie
Conditions:
Tako-TSUBO Cardiomyopathy
Acute Coronary Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
This is a case-control association study with multicentric prospective recruitment. Tako-TSUBO cardiomyopathy is a new clinical entity mimicking an acute coronary syndrome. It is characterized by rev...
Detailed Description
We hypothesize that polymorphisms in the genes involved in the adrenergic pathway resulting in greater catecholamine sensitivity would be associated with an increased risk of Tako-TSUBO cardiomyopathy...
Eligibility Criteria
Inclusion
- "Tako-TSUBO" group:
- Inclusion criteria :
- Patients presenting with Tako-TSUBO cardiomyopathy defined as: 1) an acute chest pain during a stressful incident associated with ST-segment abnormalities and/or increased serum troponin level, 2) transient left ventricular systolic dysfunction, and 3) no coronary lesions related to the left ventricular dysfunction
- Age \> 18
- Written consent
- Caucasian origin
- Affiliation to health care system
- Exclusion criteria :
- Patients presenting with pheochromocytoma
- Patients presenting with myocarditis
- Patients presenting with subarachnoid hemorrhage
- "Acute coronary syndrome" group (age- and sex-matched control group):
- Inclusion criteria :
- Patients presenting with an acute coronary syndrome (according to the definitions of guidelines)
- Age \> 18
- written consent
- Caucasian origin
- Affiliation to health care system
- Exclusion criteria :
- Patients presenting with a suspicion of Tako-TSUBO cardiomyopathy
- Patients presenting with a history of Tako-TSUBO cardiomyopathy
- "Surgical stress" group (age- and sex-matched control group):
- Inclusion criteria :
- Patients hospitalized for an urgent surgery
- Age \> 18
- Written consent
- Caucasian origin
- Affiliation to health care system
- Exclusion criteria :
- Patients presenting with increase of troponin after surgery
- Patients presenting with ECG abnormalities after surgery
- Patients presenting with a suspicion of Tako-TSUBO cardiomyopathy
- Patients presenting with a history of Tako-TSUBO cardiomyopathy
Exclusion
Key Trial Info
Start Date :
November 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2016
Estimated Enrollment :
530 Patients enrolled
Trial Details
Trial ID
NCT01520610
Start Date
November 1 2011
End Date
May 1 2016
Last Update
September 15 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Name: Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Ambroise Paré. Université de Versailles-Saint Quentin en Yvelines
Boulogne-Billancourt, Hautes Des Seine, France, 92210