Status:
COMPLETED
Complement and Graft-versus-host Disease
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Clinical haematology and BMT unit,Necker Hospital, Paris
Clinical haematology and BMT unit,Saint Antoine Hospital, Paris
Conditions:
Allografted With Myeloablative Conditioning
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Allogeneic haematopoietic stem cell transplantation (HSCT) often remains the only curative treatment for haematological malignancies. The anti-leukaemic effect of allogeneic HSCT, called the GvL (Graf...
Detailed Description
The study will be performed in allografted patients with myeloablative conditioning for an haematological malignancy from 3 adult transplant units. Patients will be followed for at least12 months aft...
Eligibility Criteria
Inclusion
- Allografted patients with myeloablative conditioning for an haematological malignancy
- Age \> 18 years old and \< 65 years.
- The patient must have access to social insurance according to local regulations.
- Patient must give a written informed consent (personally signed and dated) before completing any study related procedure
Exclusion
- Age \< 18 years old and \> 65 years
- Patient with active infection HIV, HTLV1, Hepatite B ou C
- Uncontrolled infection(s), (i.e. documented bacterial, parasitical, or fungal infection).
- Patient with lupus
- Patient with transaminases \> 5N, TP\<30% with Facteur V \< 30% before allogreffe
- Creatinine clearance \< 50ml/min
- Absence of any psychological condition potentially hampering signing informed consent
- Patient refused to sign informed consent
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT01520623
Start Date
April 1 2010
End Date
July 1 2013
Last Update
April 10 2015
Active Locations (3)
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1
Saint Louis Hospital
Paris, France, 75010
2
Saint Antoine Hospital
Paris, France, 75012
3
Necker Hospital
Paris, France, 75