Status:
COMPLETED
The Effect of Donepezil on Gait and Balance in Parkinson's Disease
Lead Sponsor:
Oregon Health and Science University
Conditions:
Parkinson's Disease
Eligibility:
All Genders
Phase:
PHASE4
Brief Summary
This study involves Parkinson's disease (PD). Symptoms include slow movement, tremor, and muscle rigidity. Current medications for the treatment of PD do not improve gait and balance difficulties in i...
Detailed Description
Parkinson's disease (PD) is a common neuro-degenerative disease affecting about 2% of the adult population in the United States over the age of 65. Some of the most disabling symptoms of Parkinson's d...
Eligibility Criteria
Inclusion
- Idiopathic Parkinson's disease, defined by the UK Brain Bank criteria, with a Hoehn and Yahr score of 2 to 4
- Treated with levodopa for at least a year and on a stable antiparkinsonian regimen for at least one month
- Abnormal computerized dynamic posturography (CDP) on screening defined as a composite score below 65 (range 1-100)
Exclusion
- Dementia defined by MMSE less than 27
- Other medical conditions other than PD affecting balance or gait as determined by the investigators
- Unable to stand unassisted for 30 minutes
- Current use of an acetylcholinesterase inhibitors or drugs with known anticholinergic properties
- Medical or psychiatric co-morbidities that may interfere with compliance or might place subject in danger as determined by the investigators
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT01521117
Start Date
December 1 2011
End Date
July 1 2012
Last Update
October 5 2021
Active Locations (1)
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1
Parkinson's Center of Oregon - Oregon Health and Science University
Portland, Oregon, United States, 97239