Status:
COMPLETED
Metoprolol in Acute Myocardial Infarction. A PK/PD Study
Lead Sponsor:
AstraZeneca
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
Phase:
PHASE1
Brief Summary
The objective of the study was to compare treatment with two different oral formulations of metoprolol, metoprolol immediate release (IR) and metoprolol extended release (CR/XL) in patients with acute...
Detailed Description
A pharmacokinetic and pharmacodynamic study comparing metoprolol IR and metoprolol CR/XL subsequent to initial treatment with intravenous and/or oral metoprolol in patients with suspected acut myocard...
Eligibility Criteria
Inclusion
- Male and female patients admitted to the CCU with suspected acute myocardial infarction
- Age 18 years or older
- Treated with and tolerated the full dose of metoprolol IR 50 mr four times daily or metoprolol CR/XL 200 mg once daily on study day 1
- Expected to stay in the CCU until the morning of study day 4
- Sinus rhythm on the day of admission and at randomisation
Exclusion
- Pregnancy or childbearing potential without adequate contraception
- Participation in a clinical study during the last 30 days or previous randomisation in the present study
Key Trial Info
Start Date :
February 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2002
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT01523054
Start Date
February 1 2000
End Date
April 1 2002
Last Update
February 1 2012
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