Status:
TERMINATED
Mechanisms of Allergen Immunotherapy
Lead Sponsor:
Royal Sussex County Hospital
Conditions:
Allergic Rhinitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Hay fever (seasonal allergic rhinitis) results from allergy to grass and tree pollen. The majority of affected individuals manage well with medication from the Pharmacy or from their general practitio...
Eligibility Criteria
Inclusion
- Male or female
- Age 18 with no upper age limit
- History of seasonal rhino-conjunctivitis in the appropriate season, not controlled by optimised standard medical therapy
- Positive skin prick test to grass pollen or tree pollen
Exclusion
- Inadequately controlled or moderate to severe asthma (GINA III/IV), i.e. the FEV1 is below 70 % of the target value despite adequate pharmacotherapy
- Irreversible changes in the reaction organ (emphysema, bronchiectasis, etc.)
- Clinically significant cardiovascular insufficiency (in cardiovascular diseases, there is an elevated risk of adverse reactions to adrenaline)
- Local or systemic use of beta blockers
- Diseases of the immune system (autoimmune diseases, immune complex-induced immunopathies, immunodeficiencies etc.)
- Malignant disease within the past five years (Patients with previous malignant disease that is considered cured may be included subject to the consent of their oncologist)
- Inability to attend regularly for injections and follow-up visits
- Severe atopic dermatitis
- Pregnant or not using adequate contraception (post-menopausal, surgically sterilised, long-term abstinent, or barrier methods plus spermicide)
- Breast-feeding
- Evidence of current drug or alcohol misuse
- Hypersensitivity to any of the SIT (immunotherapy product) excipients
- Active tuberculosis
- Severe mental disorders
- Multiple sclerosis
Key Trial Info
Start Date :
April 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT01523158
Start Date
April 1 2012
End Date
September 1 2015
Last Update
September 25 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Royal Sussex County Hospital
Brighton, United Kingdom, BN2 5BE