Status:
COMPLETED
Effects of rTMS on Cigarette Smoking and Cognition in Schizophrenia
Lead Sponsor:
Centre for Addiction and Mental Health
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Schizophrenia
Nicotine Addiction
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
Cigarette smoking rates are extremely high in persons with schizophrenia and this increases the risk of disease and death due to tobacco-related disorders. One of the features of schizophrenia is redu...
Eligibility Criteria
Inclusion
- Inclusion Criteria for all subjects:
- Have a Full Scale IQ ≥ 80 as determined by the Shipley-2 which provides an estimate of pre-morbid intelligence
- Be non-treatment seeking smokers;
- Have a score greater than 5 on the Fagerstrom Test of Nicotine Dependence (FTND), a 5-item multiple choice questionnaire which assesses nicotine dependence
- Report smoking of at least 10 cigarettes per day using a self-report 7-day timeline follow-back
- Have an expired breath CO level \>10ppm
- Be able to provide informed consent.
- Inclusion Criteria for Schizophrenia Subjects:
- Meet SCID for DSM-IV diagnostic criteria for schizophrenia or schizoaffective disorder
- Be in stable remission from positive symptoms of psychosis as judged by psychiatric evaluation and a PANSS total score \<70
- Be receiving a stable dose of antipsychotic mediation(s) for at least one month.
- Inclusion Criteria for Healthy Controls:
- Do not meet SCID for DSM-IV criteria for any current or past psychiatric disorder except for past major depression if it has been in remission for a minimum of one year
- Not taking any psychotropic medications
- General Exclusion Criteria:
- Meet criteria for abuse or dependence of alcohol or illicit substances within the past 3 months (with the exception of nicotine dependence or caffeine)
- Use of nicotine replacement or tobacco products other than cigarettes
- Concomitant medical illness (including unstable or other presentations thought by investigators to compromise study participation, e.g. diabetes mellitus, hypothyroidism or acute/chronic renal insufficiency) or neurological illness including a history of seizures or a first-degree relative with a history of a seizure disorder
- Be pregnant or planning to become pregnant
- Metallic implants.
Exclusion
Key Trial Info
Start Date :
April 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT01523730
Start Date
April 1 2012
End Date
September 1 2015
Last Update
September 9 2015
Active Locations (1)
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1
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M5T 1R8