Status:

COMPLETED

Efficacy, Safety, Tolerability and Pharmacokinetics of KAE609 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection

Lead Sponsor:

Novartis Pharmaceuticals

Conditions:

Malaria

Eligibility:

All Genders

20-60 years

Phase:

PHASE2

Brief Summary

This study will assess efficacy, safety , tolerability and PK in uncomplicated adult malaria patients with P. vivax or P. falciparum infection after 3 day dosing with KAE609 at 30 mg/day

Eligibility Criteria

Inclusion

  • Male and female patients aged 20 to 60 years
  • Presence of mono-infection of P. falciparum or P. vivax
  • Weight between 40 kg to 90 kg

Exclusion

  • Patients with signs and symptoms of severe/complicated malaria
  • Mixed Plasmodium infection
  • Presence of other serious or chronic clinical condition requiring hospitalization.
  • Severe malnutrition
  • Significant chronic medical conditions which in the opinion of the investigator preclude enrollment into the study
  • Other protocol-defined inclusion/exclusion criteria may apply.

Key Trial Info

Start Date :

January 1 2012

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

June 1 2012

Estimated Enrollment :

27 Patients enrolled

Trial Details

Trial ID

NCT01524341

Start Date

January 1 2012

End Date

June 1 2012

Last Update

May 13 2013

Active Locations (3)

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Page 1 of 1 (3 locations)

1

Novartis Investigative Site

Bangkok, Thailand, 10400

2

Novartis Investigative Site

Tak, Thailand, 63110

3

Novartis Investigative Site

Tak Province, Thailand, 63110