Status:
COMPLETED
Accelerated Aging of the Cells of Visceral Adipose Tissue in Morbid Obese Subjects
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Morbid Obesity
Eligibility:
All Genders
18-65 years
Brief Summary
Numerous epidemiological studies clearly showed the relationship between the excessive growth of visceral adipose tissue and risk of developing insulin resistance, type 2 diabetes and other cardiovasc...
Detailed Description
Main objective: The main objectives are 1) to compare the state of senescence of subcutaneous versus visceral adipose tissues and 2) to define the senescent cell populations in subcutaneous and viscer...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age between 18 and 65 y
- Social security insurance
- Candidate for bariatric surgery based on criteria established by international experts (BMI\> 40 or\> 35 kg / m² with comorbidities, after failure of multidisciplinary care for a period of at least 1 year)
- Patient having signed an informed consent
- Exclusion criteria
- Subject under guardian ship, curator ship or judicial protection.
- Subject taking anti-inflammatory and / or non-steroidal drug
- Current immunosuppressive therapy or interrupted for less than six months
- malignancy or severe inflammatory disease evolving
- Positive HIV serology and / or HBV and / or HCV
- Current pregnancy
- medical or psychiatric contraindication for bariatric surgery
Exclusion
Key Trial Info
Start Date :
February 13 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 20 2015
Estimated Enrollment :
186 Patients enrolled
Trial Details
Trial ID
NCT01525472
Start Date
February 13 2012
End Date
October 20 2015
Last Update
August 30 2021
Active Locations (1)
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1
Hopital Louis Mourier
Colombes, France, 92700