Status:
COMPLETED
Renin-angiotensin-aldosterone System (RAAS) Blockade and Contrast Induced Nephropathy
Lead Sponsor:
Soroka University Medical Center
Conditions:
Radiographic Contrast Agent Nephropathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of the current study is to evaluate prospectively whether concomitant administration of renin-angiotensin-aldosterone system (RAAS) blockers (namely ACE-I and ARBs') influence the change in es...
Detailed Description
Contrast-induced nephropathy (CIN) is defined as an absolute or relative increase in serum creatinine compared to the baseline values, together with exposure to a contrast agent and exclusion of alter...
Eligibility Criteria
Inclusion
- age \> 18 years,
- chronic therapy with ACE-I and/or ARBs' (confirmed by electronic records in their medical file) and
- planned coronary angiography
Exclusion
- chronic utilization of NSAIDS and Cox-2 selective inhibitors,
- chronic treatment with mineralocorticosteroid receptor blocker, and
- administration of contrast within 14 days prior to the enrollment.
Key Trial Info
Start Date :
February 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01525888
Start Date
February 1 2012
End Date
December 1 2013
Last Update
June 8 2015
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