Status:
COMPLETED
Brain Nicotine Receptor Density & Response to Nicotine Patch
Lead Sponsor:
Brentwood Biomedical Research Institute
Conditions:
Cigarette Smoking
Eligibility:
All Genders
18-55 years
Brief Summary
Even though the health risks and societal costs of cigarette smoking are well-known, roughly 19.8% of American adults continue to smoke. While most smokers endorse a desire to quit, very few (\< 5%) w...
Eligibility Criteria
Inclusion
- Healthy adult who is a tobacco dependent smoker (smokes 10-30 cigarettes per day) meeting criteria for Nicotine Dependence as defined by DSM-IV criteria
- Has the desire to quit smoking
- Ability to read, write, and give voluntary informed consent
- An exhaled CO greater than or equal to 8 ppm during the study screening visit to verify smoking status
Exclusion
- Any history of an Axis I psychiatric diagnosis other than Nicotine Dependence (including other substance abuse/dependence and mood, anxiety, and psychotic disorders)
- Any current medication or any history of a medical condition that might affect the central nervous system at the time of scanning (e.g., current treatment with a psychotropic medication, or history of severe head trauma or epilepsy).
- Unstable cardiovascular disease, liver disease, or renal insufficiency. Routine history and physical examination will be performed at the initial screening visit to insure that participants meet study criteria
- Pregnancy (urine pregnancy tests will be obtained on all women of child-bearing potential) due to the theoretical risk of radiation exposure to the fetus. Pre-menopausal women will only be scanned during the early follicular phase (by participant report) of the menstrual cycle because hormonal levels have been shown to affect nicotine metabolism.
- Caffeine dependence, as evidenced by withdrawal symptoms temporally associated with caffeine ingestion.
Key Trial Info
Start Date :
March 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01526005
Start Date
March 1 2012
Last Update
January 27 2015
Active Locations (1)
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1
West Los Angeles Veterans Affairs Medical Center
Los Angeles, California, United States, 90073