Status:
COMPLETED
Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome
Lead Sponsor:
Jinhua Central Hospital
Conditions:
Septic Shock
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
PHASE2
Brief Summary
PiCCO has been widely used in critical care settings for several decades. Together with pulmonary artery catheter, it is regarded as the important tool for guiding fluid management in patients with sh...
Detailed Description
PiCCO comprises techniques of pulse contour analysis and transpulmonary thermodilution, and can provide important information on hemodynamics and pulmonary functions. It has been widely used in critic...
Eligibility Criteria
Inclusion
- Patients were included if they were diagnosed with Shock, Acute respiratory distress syndrome (ARDS), or both.
- Shock was defined by the presence 4 criteria:
- Heart rate of at least 90/min;
- A respiratory rate of at least 20/min or a PaCO2 of 32mmHg or lower or the use of mechanical ventilation;
- The use of vasopressors to maintain a systolic blood pressure of at least 90mmHg despite fluid resuscitation, low dose of dopamine (≤ 5 μg/kg per minute), or dobutamine;
- at least 1 of 3 signs of hypoperfusion (urine output \< 0.5mL/kg of body weight per hour for 1 hour or more; neurologic dysfunction defined by confusion, psychosis, or a Glasgow coma scale score of ≤ 6; plasma lactate higher than the upper limit of the normal value).
- Acute respiratory distress syndrome：
- the presence of acute decrease in PaO2/FIO2 to 200mmHg or lower,
- bilateral pulmonary infiltrates or a chest radiograph consistent with edema;
- no clinical evidence of left atrial hypertension; and requirement for positive pressure ventilation.
Exclusion
- Patients were moribund.
- signed do-not-resuscitation odor.
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT01526382
Start Date
January 1 2012
End Date
June 1 2014
Last Update
May 4 2015
Active Locations (2)
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1
department of critical care medicine, Jinhua central hospital
Jinhua, Zhejiang, China, 321000
2
Traditional Chinese Medical hospital of Jinhua City
Jinhua, Zhejiang, China, 321000