Status:
UNKNOWN
68Ga-BNOTA-PRGD2 PET/CT in Healthy Volunteers and Lung Cancer Patients
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Lung Cancer
Eligibility:
All Genders
30+ years
Phase:
EARLY_PHASE1
Brief Summary
This is an open-label dynamic whole-body PET/CT (positron emission tomography/computed tomography) study for investigation of radiation dosimetry, plasma pharmacokinetics, biodistribution, safety and ...
Detailed Description
Integrin αⅤβ3 is an important member of this receptor family and expressed preferentially on various types of tumor cells and the activated endothelial cells of tumor angiogenesis, but not or very low...
Eligibility Criteria
Inclusion
- Healthy volunteers:
- Males and females, ≥30 and ≤ 70 years old
- Cancer patients:
- Males and females, ≥30 years old
- CT and/or 18F-FDG PET/CT diagnosis in suspicion of primary or recurrent lung cancer.
- The lung cancer will be histologically confirmed or results of histology will be available.
Exclusion
- Females planning to bear a child recently or with childbearing potential
- Renal function: serum creatinine \>3.0 mg/dL (270 μM/L)
- Liver function: any hepatic enzyme level more than 5 times upper limit of normal.
- Known severe allergy or hypersensitivity to IV radiographic contrast.
- Patients not able to enter the bore of the PET/CT scanner.
- Inability to lie still for the entire imaging time because of cough, pain, etc.
- Inability to complete the needed examinations due to severe claustrophobia, radiation phobia, etc.
- Concurrent severe and/or uncontrolled and/or unstable other medical disease that, in the opinion of the Investigator, may significantly interfere with study compliance.
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2017
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01527058
Start Date
December 1 2011
End Date
December 1 2017
Last Update
April 7 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Nuclear Medicine, Peking Union Medical College Hopital
Beijing, China, 100730