Status:
COMPLETED
Effects of Avenanthramide-enriched Oats on Inflammation
Lead Sponsor:
Tufts University
Collaborating Sponsors:
Agriculture and Agri-Food Canada
Conditions:
Inflammation
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The objective of this randomized, double-blinded, placebo-controlled, parallel trial is to determine whether consuming avenanthramide-enriched oats daily for 8 weeks on can improve biomarkers of infla...
Eligibility Criteria
Inclusion
- Men \& postmenopausal women, age 50 years and over
- BMI 30-36 kg/m2
- waist:hip ratio \> 0.8 for women, \> 0.9 for men
Exclusion
- Cigarette smoking and/or nicotine replacement use
- Individuals taking estrogen
- Use of cholesterol-lowering medications
- Use of blood pressure-lowering medications
- Regular use of any stomach acid-lowering medications, laxatives (including fiber supplements) or anti-diarrheal medications(prescription or over-the-counter \[OTC\])
- Cardiovascular (heart) disease
- Gastrointestinal disease
- Kidney disease
- Endocrine disease: including diabetes, untreated thyroid disease
- Rheumatoid arthritis
- Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- Systolic blood pressure \> 150 mmHg and/or diastolic blood pressure \> 95 mmHg
- Regular use of oral steroids
- Regular daily intake of ≥ 2 alcoholic drinks
- Strict vegetarians
- No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) homeopathic remedies, probiotics, or fish oil (including cod liver oil), for one month prior to study admission
Key Trial Info
Start Date :
December 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT01527604
Start Date
December 1 2012
End Date
June 1 2014
Last Update
November 19 2014
Active Locations (1)
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1
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111