Status:
COMPLETED
Exercise Capacity in Pediatric Sickle Cell Anemia
Lead Sponsor:
Ann & Robert H Lurie Children's Hospital of Chicago
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Sickle Cell Anemia
Eligibility:
All Genders
8-21 years
Brief Summary
The purpose of this study is to use comprehensive exercise testing to examine causes of exercise limitation in children and young adults with sickle cell anemia.
Detailed Description
Although the burden of sickle cell anemia (SCA) on affected individuals is significant, few studies have examined the influence of having SCA on such measures of physical function as exercise capacity...
Eligibility Criteria
Inclusion
- age 10 to 21 years old; AND
- Hb SS or S-β0 thalassemia disease, confirmed by hemoglobin analysis
Exclusion
- inability to perform maximal testing due to physical limitation (e.g. stroke or avascular necrosis); OR
- history of exercise-induced syncope or arrhythmias. Subjects will wait at least 2 weeks following any vaso-occlusive pain episode and 12 weeks following any disease-related complication requiring transfusion support. Individuals on hydroxyurea will be eligible. A total of 30 controls without SCA or sickle cell trait will be matched for age, sex and race and recruited from the siblings, friends or relatives of subjects enrolled on this study
Key Trial Info
Start Date :
June 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01527799
Start Date
June 1 2009
End Date
July 1 2015
Last Update
February 4 2016
Active Locations (1)
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1
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611