Status:
COMPLETED
Initiation of Cooling by EMS to Promote Adoption of In-hospital Hypothermia in Cardiac Arrest Survivors
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Out of Hospital Cardiac Arrest
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a large pragmatic, randomized controlled trial comparing pre-hospital initiation of therapeutic hypothermia by Emergency Medical Services (EMS) providers to conventional post-resuscitation car...
Detailed Description
This is a large pragmatic, randomized controlled trial comparing pre-hospital initiation of therapeutic hypothermia by Emergency Medical Services (EMS) providers to conventional post-resuscitation car...
Eligibility Criteria
Inclusion
- Pulseless OHCA in the study communities (any rhythm, initial rhythm will be recorded)
- Age equal to or greater than 18 years
- Defibrillation and/or chest compressions by EMS providers (including fire fighters)
- Return of spontaneous circulation (ROSC) sustained for greater than or equal to 5 minutes
- Patient is unresponsive to verbal stimulus using AVPU (Alert, Voice, Pain, Unresponsive) scale
- Patient is endotracheally intubated
- SBP equal to or greater than 100 mm Hg (even if needing dopamine)
Exclusion
- Trauma (including burns) associated with cardiac arrest
- Sepsis or serious infection suspected as cause of cardiac arrest
- Clinical evidence of active severe bleeding
- Suspected hypothermic cardiac arrest
- Known coagulopathy (medical history or medications; ASA and clopidogrel are permitted)
- Any verbal or written do-not-resuscitate (DNR)
- Obviously pregnant
- Known Prisoner
Key Trial Info
Start Date :
July 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
585 Patients enrolled
Trial Details
Trial ID
NCT01528475
Start Date
July 1 2012
End Date
June 1 2016
Last Update
December 19 2016
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Peel Emergency Medical Services
Mississauga, Ontario, Canada
2
Halton Emergency Medical Services
Oakville, Ontario, Canada
3
Toronto Emergency Medical Services
Toronto, Ontario, Canada