Status:
COMPLETED
Obstructive Sleep Apnea (OSA), Hypertension , β1 Subunit of Maxi-k+ Channel and Cardiovascular Risk
Lead Sponsor:
Angeles Sanchez Armengol
Collaborating Sponsors:
Junta de Andalucia
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
18-75 years
Brief Summary
To describe the relationship between OSA and clinical Hypertension (performing ABPM), endothelial dysfunction (performing flowmetry), and its relation at the basic research (determining the β1 subunit...
Detailed Description
Background: Several epidemiological studies have demonstrated that untreated OSA with continuous positive airway pressure, is related to high rates of cardiovascular morbidity and mortality, being HTA...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- The control group was defined as "absence of OSA"(apnea-hypopnea index (AHI) in cardiorespiratory polygraphy \<5).
- The "OSA" group was defined as OSA symptoms + an AHI ≥ 15 in cardiorespiratory polygraphy
- Exclusion criteria:
- Awaking hypoxemia (PO2 in arterial blood gas \<70 mmHg) or arterial saturation \<90% in digital pulse oximetry.
- Treated hypertensive patients who were not well controlled at the time of inclusion: change of HTA treatment in the previous 3 months.
Exclusion
Key Trial Info
Start Date :
February 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01791270
Start Date
February 1 2010
End Date
December 1 2012
Last Update
June 21 2013
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